Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 20/20 | 0.64 |
| ▸ | JAK2 | O60674 | 19/20 | 0.64 |
| ▸ | CDK2 | P24941 | 18/20 | 0.64 |
| ▸ | CCNA2 | P20248 | 15/20 | 0.64 |
| ▸ | CCNA1 | P78396 | 15/20 | 0.64 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.64 |
| ▸ | TYK2 | P29597 | 11/20 | 0.54 |
| ▸ | JAK1 | P23458 | 7/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823901 | 0.90 | FLT3 (0.78) | FLT3JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL823966 | 0.87 | FLT3 (0.71) | FLT3JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL13676178 | 0.86 | FLT3 (0.55) | FLT3JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL13675497 | 0.85 | FLT3 (0.54) | FLT3JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL823914 | 0.79 | JAK2 (1.00) | FLT3JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL823837 | 0.77 | FLT3 (0.69) | FLT3JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL13675517 | 0.77 | FLT3 (0.53) | FLT3JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL13675498 | 0.74 | JAK2 (0.69) | FLT3JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL18793192 | 0.73 | JAK2 (0.80) | FLT3JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL13675518 | 0.73 | FLT3 (0.49) | FLT3JAK2CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143255-B2 | Heteroalkyl linked pyrimidine derivatives | S*BIO PTE LTD. (SG) | 2012-03-27 | — | — | US | disclosed |
| US-8143255-B2 | Heteroalkyl linked pyrimidine derivatives | S*BIO PTE LTD. (SG) | 2012-03-27 | — | — | US | disclosed |