Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 20/20 | 0.53 |
| ▸ | JAK2 | O60674 | 19/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 16/20 | 0.53 |
| ▸ | CDK2 | P24941 | 16/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 16/20 | 0.53 |
| ▸ | TYK2 | P29597 | 11/20 | 0.53 |
| ▸ | JAK3 | P52333 | 5/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 9/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823896 | 0.85 | CDK2 (0.67) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL12921876 | 0.82 | FLT3 (0.52) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL12948386 | 0.80 | FLT3 (0.54) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL824028 | 0.79 | CDK2 (0.74) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL12921806 | 0.79 | FLT3 (0.51) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL14731347 | 0.77 | PLK4 (0.57) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL824025 | 0.77 | FLT3 (0.64) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL12948334 | 0.77 | FLT3 (0.52) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL12921845 | 0.76 | FLT3 (0.47) | FLT3JAK2CCNA2CDK2CCNA1 | |
| SCHEMBL823984 | 0.76 | FLT3 (0.75) | FLT3JAK2CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258886-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2009-10-15 | — | — | US | disclosed |
| US-20090258886-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258886-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | TK1, TK2, DPYD | FLT3 424/4885JAK2 692/4885CCNA2 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.