Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.51 |
| ▸ | AKT2 | P31751 | 8/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583865 | 0.95 | AKT1 (0.53) | AKT1AKT2AKT3EGFRPIM1 | |
| SCHEMBL4582831 | 0.90 | AKT1 (0.50) | AKT1AKT2AKT3EGFRPIM1 | |
| SCHEMBL4584125 | 0.83 | AKT1 (0.68) | AKT1AKT2AKT3EGFRPIM1 | |
| SCHEMBL4583125 | 0.83 | AKT1 (0.49) | AKT1AKT2AKT3 | |
| SCHEMBL4582695 | 0.81 | AKT1 (0.67) | AKT1AKT2AKT3EGFRPIM1 | |
| SCHEMBL4583224 | 0.78 | AKT1 (0.50) | AKT1AKT2AKT3 | |
| SCHEMBL4583110 | 0.74 | AKT1 (0.55) | AKT1AKT2AKT3EGFRPIM1 | |
| SCHEMBL8240248 | 0.74 | AKT1 (0.71) | AKT1AKT2AKT3EGFRPIM1 | |
| SCHEMBL4583618 | 0.74 | AKT1 (0.69) | AKT1AKT2AKT3EGFRPIM1 | |
| SCHEMBL4584175 | 0.73 | AKT1 (0.47) | AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |