Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.50 |
| ▸ | AKT2 | P31751 | 5/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.46 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583125 | 0.96 | AKT1 (0.49) | AKT1AKT2AKT3 | |
| SCHEMBL4584175 | 0.91 | AKT1 (0.47) | AKT1AKT2AKT3 | |
| SCHEMBL4583793 | 0.84 | AKT1 (0.65) | AKT1AKT2AKT3 | |
| SCHEMBL4583865 | 0.81 | AKT1 (0.53) | AKT1AKT2AKT3 | |
| SCHEMBL8240263 | 0.78 | AKT1 (0.51) | AKT1AKT2AKT3 | |
| SCHEMBL8240619 | 0.75 | AKT1 (0.69) | AKT1AKT2AKT3 | |
| SCHEMBL4582831 | 0.72 | AKT1 (0.50) | AKT1AKT2AKT3 | |
| SCHEMBL4581720 | 0.72 | AKT1 (0.41) | AKT1NEK1 | |
| SCHEMBL4592540 | 0.70 | AKT1 (0.67) | AKT1AKT2AKT3NEK1 | |
| SCHEMBL19390620 | 0.69 | RAB9A (0.43) | NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |