Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 6/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.31 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28119348 | 0.79 | TP53 (0.41) | TP53L3MBTL1FOLH1FFAR1TBXA2R | |
| SCHEMBL3595515 | 0.74 | L3MBTL1 (0.38) | TP53L3MBTL1FFAR1ACEALDH1A1 | |
| SCHEMBL10361424 | 0.74 | TP53 (0.48) | TP53L3MBTL1POLBATMFFAR1 | |
| SCHEMBL3582079 | 0.73 | PPARD (0.40) | TP53L3MBTL1FFAR1ALDH1A1TDP1 | |
| SCHEMBL14646817 | 0.69 | — | — | |
| SCHEMBL7414681 | 0.69 | TP53 (0.62) | TP53L3MBTL1POLBFOLH1ITGB3 | |
| SCHEMBL10642674 | 0.69 | TP53 (0.62) | TP53L3MBTL1POLBFOLH1ITGB3 | |
| SCHEMBL21682181 | 0.67 | TP53 (0.37) | TP53L3MBTL1POLBFFAR1ITGB3 | |
| SCHEMBL21682218 | 0.67 | TP53 (0.37) | TP53L3MBTL1POLBFFAR1ITGB3 | |
| SCHEMBL879579 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948603-B1 | TETRAHYDROINDOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2011-08-10 | — | — | EP | disclosed |
| WO-2007054739-A1 | TETRAHYDROINDOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |