Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 11/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.38 |
| ▸ | UBASH3B | Q8TF42 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198076 | 0.88 | F11 (0.53) | F11ROCK2KLKB1PRSS1PRSS2 | |
| SCHEMBL1198074 | 0.88 | F11 (0.53) | F11ROCK2KLKB1PRSS1PRSS2 | |
| SCHEMBL1195928 | 0.82 | F11 (0.49) | F11ROCK2KLKB1PRSS1PRSS2 | |
| SCHEMBL13387419 | 0.81 | F11 (0.40) | F11KLKB1UBASH3BTRPV1 | |
| SCHEMBL13387420 | 0.79 | F11 (0.39) | F11KLKB1UBASH3BMAPK1TRPV1 | |
| SCHEMBL13552343 | 0.79 | F11 (0.43) | F11ROCK2KLKB1PRSS1PRSS2 | |
| SCHEMBL1196691 | 0.77 | F11 (0.50) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL1196693 | 0.77 | F11 (0.50) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL1196558 | 0.77 | F11 (0.65) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL1196556 | 0.77 | F11 (0.65) | F11KLKB1PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007070826-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |