Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL414796 | 0.89 | BRAF (0.44) | BRAFGRM8GRM4CAMKK2MAP2K1 | |
| SCHEMBL9983982 | 0.85 | BRAF (0.41) | BRAFGRM8GRM4CAMKK2MAP2K1 | |
| SCHEMBL414305 | 0.84 | GRM8 (0.40) | BRAFGRM8GRM4ROCK2ADORA2A | |
| SCHEMBL3701115 | 0.82 | CAMKK2 (0.43) | BRAFGRM8GRM4CAMKK2MAP2K1 | |
| SCHEMBL3701118 | 0.81 | GRM8 (0.40) | BRAFGRM8GRM4CAMKK2MAP2K1 | |
| SCHEMBL298499 | 0.80 | BRAF (0.49) | BRAFMAP2K1CDK8MAP4K4HIPK2 | |
| SCHEMBL13138570 | 0.78 | BRAF (0.39) | BRAFGRM8GRM4CAMKK2MAP2K1 | |
| SCHEMBL8247765 | 0.78 | CYP3A4 (0.44) | BRAFCDC7CYP3A4 | |
| SCHEMBL858392 | 0.77 | AAK1 (0.46) | DYRK1ACYP3A4 | |
| SCHEMBL858505 | 0.76 | GRM8 (0.38) | BRAFGRM8GRM4CAMKK2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002325-A1 | PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |