SCHEMBL824112

SCHEMBL824112

CC(C)CC(F)(F)F

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21758880 0.80
SCHEMBL24275751 0.77
SCHEMBL7865165 0.77
SCHEMBL12570877 0.77
SCHEMBL2625540 0.74
SCHEMBL765868 0.74
SCHEMBL2431031 0.74
SCHEMBL727845 0.74
SCHEMBL17885875 0.74
SCHEMBL23748394 0.74 ALDH1A1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 720 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11964968-B2 Compounds useful for inhibiting RET kinase ELI LILLY AND COMPANY (US) 2024-04-23 US claimed
US-20230399297-A1 Novel Glutamine Analogs JACOBIO PHARMACEUTICALS CO., LTD (CN) 2023-12-14 US claimed
US-20230312544-A1 COMPOUNDS USEFUL FOR INHIBITING RET KINASE LOXO ONCOLOGY, INC. 2023-10-05 US claimed
US-20230265085-A1 RET KINASE INHIBITORS LOXO ONCOLOGY, INC. 2023-08-24 US claimed
US-11697647-B2 RET kinase inhibitors ELI LILLY AND COMPANY (US) 2023-07-11 US claimed
US-11613533-B2 Compounds useful for inhibiting RET kinase ELI LILLY AND COMPANY (US) 2023-03-28 US claimed
EP-4143184-A1 COMPOUNDS USEFUL FOR INHIBITING RET KINASE Eli Lilly and Company (US) 2023-03-08 EP claimed
US-20220233971-A1 CLOSED ROTATABLE EXTRACTOR SYSTEM BREVETS, LLC 2022-07-28 US claimed
US-20220144816-A1 RET KINASE INHIBITORS EVOTEC INTERNATIONAL GMBH (DE) 2022-05-12 US claimed
US-20210363140-A1 COMPOUNDS USEFUL FOR INHIBITING RET KINASE LOXO ONCOLOGY, INC. 2021-11-25 US claimed
EP-1711577-A2 HYDROFLUOROCARBON REFRIGERANT COMPOSITIONS AND USES THEREOF E.I. du Pont de Nemours and Company (US) 2006-10-18 EP claimed
EP-1706468-A2 1,1,1,3,3-PENTAFLUOROBUTANE REFRIGERANT OR HEAT TRANSFER FLUID COMPOSITIONS COMPRISING HYDROFLUOROCARBON AND USES THEREOF E.I.Du pont de nemours and company (US) 2006-10-04 EP claimed
US-20060208216-A1 1,1,1,2,2,4,5,5,5-Nonafluoro-4-(trifluoromethyl)-3-pentanone compositions comprising a hydrofluorocarbon and uses thereof MINOR BARBARA H 2006-09-21 US claimed
WO-2005119143-A2 1,1,1,2,2,4,5,5,5-NONAFLUORO-4-(TRIFLUOROMETHYL)-3-PENTANONE COMPOSITIONS COMPRISING A HYDROFLUOROCARBON AND USES THEREOF E.I. DUPONT DE NEMOURS AND COMPANY (US) 2005-12-15 WO claimed
US-20050263737-A1 1,1,1,2,2,4,5,5,5-NONAFLUORO-4-(TRIFLUOROMETHYL)-3-PENTANONE COMPOSITIONS COMPRISING A HYDROFLUOROCARBON AND USES THEREOF E. I. DU PONT DE NEMOURS AND COMPANY 2005-12-01 US claimed
WO-2005067554-A2 HYDROFLUOROCARBON REFRIGERANT COMPOSITIONS AND USES THEREOF E.I. DUPONT DE NEMOURS AND COMPANY (US) 2005-07-28 WO claimed
WO-2005067555-A2 1,1,1,3,3-PENTAFLUOROBUTANE REFRIGERANT OR HEAT TRANSFER FLUID COMPOSITIONS COMPRISING HYDROFLUOROCARBON AND USES THEREOF E.I. DUPONT DE NEMOURS AND COMPANY (US) 2005-07-28 WO claimed
US-20050151113-A1 Hydrofluorocarbon refrigerant compositions and uses thereof E. I. DU PONT DE NEMOURS AND COMPANY 2005-07-14 US claimed
US-20050151111-A1 1,1,1,3,3-Pentafluorobutane refrigerant or heat transfer fluid compositions comprising hydrofluorocarbon and uses thereof E. I. DU PONT DE NEMOURS AND COMPANY 2005-07-14 US claimed
US-20050151112-A1 1,1,1,2,2,3,3,4,4-Nonafluoro-4-methoxybutane refrigerant compositions comprising hydrofluorocarbon, and uses thereof E. I. DU PONT DE NEMOURS AND COMPANY 2005-07-14 US claimed