Thapsigargin

Thapsigargin

SCHEMBL82423

C/C=C(/C)C(=O)O[C@H]1C(C)=C2[C@H]([C@@H]1OC(=O)CCCCCCC)[C@@](C)(OC(C)=O)C[C@H](OC(=O)CCC)[C@@]1(O)[C@H]2OC(=O)[C@@]1(C)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 1.00
HPGD P15428 2/20 1.00
POLB P06746 2/20 1.00
MAPK1 P28482 2/20 1.00
KMT2A Q03164 2/20 1.00
NPSR1 Q6W5P4 2/20 1.00
NPC1 O15118 2/20 1.00
RAB9A P51151 2/20 1.00
MEN1 O00255 1/20 1.00
GMNN O75496 1/20 1.00
ALDH1A1 P00352 1/20 1.00
LMNA P02545 1/20 1.00
GLA P06280 1/20 1.00
GAA P10253 1/20 1.00
APEX1 P27695 1/20 1.00
BLM P54132 1/20 1.00
PMP22 Q01453 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
ATP2A1 O14983 1/20 1.00
MTOR P42345 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thapsigargin SCHEMBL21981209 1.00 MAPT (1.00) MAPTHPGDPOLBMAPK1KMT2A
Thapsigargin SCHEMBL18762158 1.00 MAPT (1.00) MAPTHPGDPOLBMAPK1KMT2A
Thapsigargin SCHEMBL18762159 1.00 MAPT (1.00) MAPTHPGDPOLBMAPK1KMT2A
Thapsigargin SCHEMBL5690389 1.00 MAPT (1.00) MAPTHPGDPOLBMAPK1KMT2A
Thapsigargin SCHEMBL21981207 1.00 MAPT (1.00) MAPTHPGDPOLBMAPK1KMT2A
Thapsigargin SCHEMBL16491487 1.00 MAPT (1.00) MAPTHPGDPOLBMAPK1KMT2A
Thapsigargin SCHEMBL20897006 0.99 MAPT (0.99) MAPTHPGDPOLBMAPK1KMT2A
SCHEMBL21900317 0.99 MAPT (1.00) MAPTHPGDPOLBMAPK1KMT2A
SCHEMBL18080775 0.96 MAPT (0.93) MAPTHPGDPOLBMAPK1KMT2A
SCHEMBL18082023 0.96 MAPT (0.93) MAPTHPGDPOLBMAPK1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 10814 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES TRAILHEAD BIOSYSTEMS INC (US) 2026-05-07 US claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-12600969-B2 Expression control using a regulatable intron AskBio Inc. (US) 2026-04-14 US claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
US-20260070068-A1 AMMONIATED POLYCARBAMIDE SEPARATION AIDS FOR MINERAL FLOTATION HEXION INC. (US) 2026-03-12 US claimed
EP-3947736-B1 PROGNOSIS METHOD OF CANCER CENTRE NAT RECH SCIENT (FR) 2026-03-11 EP claimed
US-20260048156-A1 FAP-TARGETING PHARMACEUTICAL PRODUCT FOR THERAPY AND DIAGNOSIS OF CANCERS Atoms for Cure GmbH (DE) 2026-02-19 US claimed
US-20260028400-A1 ANTI-ROR1 ANTIBODY AND USE THEREOF AIMED BIO INC (KR) 2026-01-29 US claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
US-5646185-A Tumor treatment method THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1997-07-08 US claimed
EP-0778848-A1 AGENTS FOR INDUCING APOPTOSIS AND APPLICATIONS OF SAID AGENTS IN THERAPY University of Dundee (GB) 1997-06-18 EP claimed
WO-1997004761-A9 METHODS AND COMPOSITIONS FOR TREATING CELL PROLIFERATIVE DISORDERS 1997-05-29 WO claimed
EP-0760855-A1 HEPATITIS C VIRUS ASIALOGLYCOPROTEINS CHIRON CORPORATION (US) 1997-03-12 EP claimed
WO-1997004761-A1 METHODS AND COMPOSITIONS FOR TREATING CELL PROLIFERATIVE DISORDERS TRUSTEES OF BOSTON UNIVERSITY (US) 1997-02-13 WO claimed
WO-1996036334-A1 USE OF CALCIUM INTRACELLULAR STORE INACTIVATORS AND FORMULATIONS THEREOF AS CELL GROWTH INHIBITORS UNIVERSITY OF EAST ANGLIA (GB) 1996-11-21 WO claimed
US-5538983-A Method of treating amyloidosis by modulation of calcium THE ROCKEFELLER UNIVERSITY (US) 1996-07-23 US claimed
WO-1996006863-A1 AGENTS FOR INDUCING APOPTOSIS AND APPLICATIONS OF SAID AGENTS IN THERAPY UNIVERSITY OF DUNDEE (GB) 1996-03-07 WO claimed
WO-1995033053-A1 HEPATITIS C VIRUS ASIALOGLYCOPROTEINS CHIRON CORPORATION (US) 1995-12-07 WO claimed
WO-1995010273-A1 USE OF PROTEIN KINASE C ACTIVATORS FOR THE MANUFACTURE OF A MEDICAMENT FOR KILLING HYPOXIC TUMOR CELLS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1995-04-20 WO claimed