Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 4/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26161883 | 1.00 | APLNR (0.45) | APLNRFPR2TSHRPDE2ARORC | |
| SCHEMBL15235824 | 0.85 | TSHR (0.38) | APLNRFPR2TSHRRORCDGAT1 | |
| SCHEMBL29784759 | 0.83 | APLNR (0.48) | APLNRPDE2ADGAT1KDM1AKDM1B | |
| SCHEMBL15092400 | 0.83 | APLNR (0.44) | APLNRFPR2PDE2ADGAT1PYCR1 | |
| SCHEMBL2879129 | 0.83 | APLNR (0.44) | APLNRFPR2PDE2ADGAT1PYCR1 | |
| SCHEMBL18839718 | 0.83 | APLNR (0.48) | APLNRPDE2ADGAT1KDM1AKDM1B | |
| SCHEMBL12267174 | 0.83 | APLNR (0.44) | APLNRFPR2PDE2ADGAT1PYCR1 | |
| SCHEMBL12278795 | 0.80 | APLNR (0.49) | APLNRDGAT1PYCR1ACACBOPRM1 | |
| SCHEMBL12686652 | 0.80 | MC4R (0.41) | TSHRPDE2ARORC | |
| SCHEMBL12686634 | 0.80 | MC4R (0.41) | TSHRPDE2ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007050576-A2 | A METHOD OF PREPARING A 4-OXO-1- (3 SUBSTITUTED PHENYL) -1, 4-DIHYDRO-1, 8-NAPHTHYRIDINE-3- CARBOXAMIDE PHOSPHODIESTERASE-4 INHIBITOR | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |