Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.50 |
| ▸ | AKT2 | P31751 | 9/20 | 0.50 |
| ▸ | AKT3 | Q9Y243 | 8/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4584714 | 0.86 | AKT1 (0.64) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL8242957 | 0.86 | AKT1 (0.64) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL8242383 | 0.85 | AKT1 (0.51) | AKT1AKT2AKT3ROCK1CDC7 | |
| SCHEMBL8241403 | 0.79 | AKT1 (0.74) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL4584069 | 0.79 | AKT1 (0.53) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL4584368 | 0.75 | AKT1 (0.59) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL4581831 | 0.75 | AKT1 (0.69) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL4583613 | 0.73 | AKT1 (0.67) | AKT1AKT2AKT3ROCK1EGFR | |
| SCHEMBL4348278 | 0.73 | GSK3B (0.52) | AKT1AKT2AKT3ADORA2AGSK3B | |
| SCHEMBL4348275 | 0.73 | GSK3B (0.52) | AKT1AKT2AKT3ADORA2AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |