Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KRAS | P01116 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 6/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL66061 | 0.83 | HRH3 (0.41) | HRH3KRASNPY5RF10TP53 | |
| SCHEMBL57307 | 0.79 | HRH3 (0.48) | HRH3KRASF10TP53MAPT | |
| SCHEMBL65671 | 0.78 | F10 (0.44) | HRH3KRASNPY5RF10TP53 | |
| SCHEMBL57175 | 0.77 | TACR1 (0.43) | HRH3KRASNPY5RF10TP53 | |
| SCHEMBL56764 | 0.74 | F10 (0.44) | HRH3KRASNPY5RF10MAPT | |
| SCHEMBL66257 | 0.74 | F2 (0.43) | HRH3NPY5RF10TP53MAPT | |
| SCHEMBL8242528 | 0.72 | MEN1 (0.50) | HRH3KRASF10TP53MAPT | |
| SCHEMBL8243869 | 0.67 | SMN1; SMN2 (0.43) | MAPT | |
| SCHEMBL1576317 | 0.65 | SCN9A (0.44) | F10 | |
| SCHEMBL10310789 | 0.65 | F10 (0.44) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007050522-A1 | DERIVATIVES FOR MODULATION OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-03 | — | — | WO | disclosed |