SCHEMBL824420

SCHEMBL824420

O=C(O)c1ccc2c(c1)nc1n2c2nc3ccc(C(=O)O)cc3n2c2nc3cc(C(=O)O)ccc3n12

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.48
TDP1 Q9NUW8 1/20 0.47
HTT P42858 1/20 0.47
HCAR3 P49019 7/20 0.46
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
HPGD P15428 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
GAA P10253 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
FGFR1 P11362 2/20 0.43
HCAR2 Q8TDS4 1/20 0.43
ACSS2 Q9NR19 1/20 0.41
THRB P10828 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL824415 1.00 HSD17B10 (0.48) HSD17B10TDP1HTTHCAR3NPC1
SCHEMBL824437 0.93 TDP1 (0.49) HSD17B10TDP1HTTHCAR3NPC1
SCHEMBL824442 0.93 HSD17B10 (0.53) HSD17B10TDP1HTTHCAR3NPC1
SCHEMBL16488365 0.82 PDE2A (0.40) HSD17B10TDP1HCAR3NPC1RAB9A
SCHEMBL18818916 0.78 FGFR1 (0.48) HSD17B10HTTHCAR3NPC1RAB9A
SCHEMBL7606903 0.76 KMT2A (0.53) HSD17B10TDP1HTTHCAR3NPC1
SCHEMBL7604980 0.76 KMT2A (0.53) HSD17B10TDP1HTTHCAR3NPC1
SCHEMBL4549641 0.75 HSD17B10 (0.43) HSD17B10TDP1HTTHCAR3NPC1
SCHEMBL4549640 0.75 TDP1 (0.42) HSD17B10TDP1HTTHCAR3NPC1
SCHEMBL4549638 0.74 HSD17B10 (0.40) HSD17B10TDP1HTTHCAR3NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2291703-B1 COLOR LIQUID CRYSTAL DISPLAY AND COMPENSATION PANEL CRYSOPTIX KK (JP) 2016-11-30 EP disclosed
EP-2638126-B1 NEGATIVE DISPERSION RETARDATION PLATE AND ACHROMATIC CIRCULAR POLARIZER CRYSOPTIX KK (JP) 2015-02-18 EP disclosed
US-8895118-B2 Negative dispersion retardation plate and achromatic circular polarizer CRYSOPTIX K.K. (JP) 2014-11-25 US disclosed
US-8895118-B2 Negative dispersion retardation plate and achromatic circular polarizer CRYSOPTIX K.K. (JP) 2014-11-25 US disclosed
US-8416376-B2 Compensated in-plane switching mode liquid crystal display CRYSOPTIX KK (JP) 2013-04-09 US disclosed
US-8416376-B2 Compensated in-plane switching mode liquid crystal display CRYSOPTIX KK (JP) 2013-04-09 US disclosed
US-20120113380-A1 NEGATIVE DISPERSION RETARDATION PLATE AND ACHROMATIC CIRCULAR POLARIZER CRYSOPTIX KK (JP) 2012-05-10 US disclosed
US-20120113380-A1 NEGATIVE DISPERSION RETARDATION PLATE AND ACHROMATIC CIRCULAR POLARIZER CRYSOPTIX KK (JP) 2012-05-10 US disclosed
US-8142863-B2 Color liquid crystal display and compensation panel Crysoptix, KK (JP) 2012-03-27 US disclosed
US-8142863-B2 Color liquid crystal display and compensation panel Crysoptix, KK (JP) 2012-03-27 US disclosed
US-7889297-B2 Liquid crystal display operating in a vertically aligned mode Crysoptix, KK (JP) 2011-02-15 US disclosed
US-7889297-B2 Liquid crystal display operating in a vertically aligned mode Crysoptix, KK (JP) 2011-02-15 US disclosed
US-20100279122-A1 Benzimidazole, Benzoxazole and Benzothiazole Derivatives, Optical Film Comprising them and Method of Producing thereof CRYSOPTIX KK (JP) 2010-11-04 US disclosed
US-20100279122-A1 Benzimidazole, Benzoxazole and Benzothiazole Derivatives, Optical Film Comprising them and Method of Producing thereof CRYSOPTIX KK (JP) 2010-11-04 US disclosed
US-20100149471-A1 Compensated In-Plane Switching Mode Liquid Crystal Display CRYSOPTIX KK (JP) 2010-06-17 US disclosed
US-20100149471-A1 Compensated In-Plane Switching Mode Liquid Crystal Display CRYSOPTIX KK (JP) 2010-06-17 US disclosed
US-20100118241-A1 Liquid Crystal Display Operating in a Vertically Aligned Mode CRYSOPTIX KK (JP) 2010-05-13 US disclosed
US-20100118241-A1 Liquid Crystal Display Operating in a Vertically Aligned Mode CRYSOPTIX KK (JP) 2010-05-13 US disclosed
US-20090268136-A1 Color Liquid Crystal Display and Compensation Panel CRYSOPTIX KK (JP) 2009-10-29 US disclosed
US-20090268136-A1 Color Liquid Crystal Display and Compensation Panel CRYSOPTIX KK (JP) 2009-10-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100279122-A1 Benzimidazole, Benzoxazole and Benzothiazole Derivatives, Optical Film Comprising them and Method of Producing thereof BMX, ABCG2, BRI3BP HSD17B10 2693/4885TDP1 3607/4885HTT 2511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.