SCHEMBL8244239

SCHEMBL8244239

CNC(=O)c1ccc(Cl)s1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.62
MAPT P10636 3/20 0.62
F2 P00734 1/20 0.57
DAO P14920 1/20 0.57
MAPK1 P28482 3/20 0.56
RAB9A P51151 7/20 0.54
KMT2A Q03164 6/20 0.54
LMNA P02545 3/20 0.54
NPC1 O15118 6/20 0.53
ALDH1A1 P00352 5/20 0.53
HPGD P15428 5/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
TP53 P04637 1/20 0.53
NFKB1 P19838 1/20 0.53
CASP1 P29466 1/20 0.53
CASP7 P55210 1/20 0.53
NFKB2 Q00653 1/20 0.53
RELA Q04206 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
GSK3B P49841 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12216734 0.84 KDM4E (0.62) KDM4EMAPTRAB9AKMT2ALMNA
SCHEMBL4211785 0.79 KDM4E (0.53) KDM4EMAPTF2MAPK1RAB9A
SCHEMBL166992 0.79 F2 (0.63) KDM4EMAPTF2DAOMAPK1
SCHEMBL13754450 0.79 SMN1; SMN2 (0.59) KDM4EMAPTF2DAOMAPK1
SCHEMBL27572930 0.79 F2 (0.52) KDM4EMAPTF2DAOMAPK1
SCHEMBL14627824 0.79 MAPK1 (0.64) KDM4EF2DAOMAPK1RAB9A
SCHEMBL3241403 0.79 AR (0.52) KDM4EMAPTF2DAOMAPK1
SCHEMBL265403 0.78 HPGD (0.49) KDM4EMAPTF2DAOMAPK1
SCHEMBL6395252 0.77 KDM4E (0.55) KDM4EMAPTRAB9AKMT2ALMNA
SCHEMBL7967944 0.77 KMT2A (0.59) KDM4EMAPTDAORAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230295136-A1 Analogs of Nitrofuran Antibiotics to Combat Resistance ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA 2023-09-21 US disclosed
EP-3309158-B1 CRYSTALLINE FORM K OF RIVAROXABAN AND PROCESS FOR ITS PREPARATION KRKA TOVARNA ZDRAVIL D D (SI) 2022-03-16 EP disclosed
EP-3309158-B1 CRYSTALLINE FORM K OF RIVAROXABAN AND PROCESS FOR ITS PREPARATION KRKA TOVARNA ZDRAVIL D D (SI) 2022-03-16 EP disclosed
US-20220009914-A1 Analogs of Nitrofuran Antibiotics to Combat Resistance NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-01-13 US disclosed
WO-2019003141-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-01-03 WO disclosed
EP-2968995-B1 INHIBITORS OF LRRK2 KINASE ACTIVITY ELAN PHARMACEUTICALS LLC (US) 2018-05-09 EP disclosed
EP-3309158-A1 CRYSTALLINE FORM K OF RIVAROXABAN AND PROCESS FOR ITS PREPARATION Farma GRS, d.o.o. (SI) 2018-04-18 EP disclosed
EP-3309158-A1 CRYSTALLINE FORM K OF RIVAROXABAN AND PROCESS FOR ITS PREPARATION Farma GRS, d.o.o. (SI) 2018-04-18 EP disclosed
US-9828350-B2 5,6-dihydro-2H-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (BACE) JANSSEN PHARMACEUTICA NV (BE) 2017-11-28 US disclosed
EP-2935255-B1 A PROCESS FOR PREPARATION OF RIVAROXABAN FARMA GRS D O O (SI) 2017-08-16 EP disclosed
WO-2014096214-A1 A PROCESS FOR PREPARATION OF RIVAROXABAN FARMA GRS, D.O.O. (SI) 2014-06-26 WO disclosed
WO-2014096214-A1 A PROCESS FOR PREPARATION OF RIVAROXABAN FARMA GRS, D.O.O. (SI) 2014-06-26 WO disclosed
WO-2013120465-A1 A PROCESS FOR THE PREPARATION OF RIVAROXABAN BASED ON THE USE OF (S)-EPICHLOROHYDRIN ZENTIVA, K.S. (CZ) 2013-08-22 WO disclosed
US-20130137730-A1 INHIBITOR OF CASEIN KINASE 1DELTA AND CASEIN KINASE 1E NB HEALTH LABORATORY CO., LTD. (JP) 2013-05-30 US disclosed
US-20130109683-A1 5,6-DIHYDRO-2H-[1,4]OXAZIN-3-YL-AMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) JANSSEN PHARMACEUTICA NV (US) 2013-05-02 US disclosed
US-20130109683-A1 5,6-DIHYDRO-2H-[1,4]OXAZIN-3-YL-AMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) JANSSEN PHARMACEUTICA NV (US) 2013-05-02 US disclosed
EP-2132193-B1 SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS BOEHRINGER INGELHEIM INT (DE) 2012-10-24 EP disclosed
WO-2007042146-A1 MICROANGIOPATHY TREATMENT AND PREVENTION BAYER HEALTHCARE AG (DE) 2007-04-19 WO disclosed
WO-2005032468-A2 MONOCYCLIC AND BICYCLIC LACTAMS AS FACTOR XA INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2005-04-14 WO disclosed
WO-2004082687-A1 LACTAM-CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2004-09-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230295136-A1 Analogs of Nitrofuran Antibiotics to Combat Resistance ATF4, ATF1, FBL KDM4E 2340/4885MAPT 4442/4885F2 4738/4885
US-20130109683-A1 5,6-DIHYDRO-2H-[1,4]OXAZIN-3-YL-AMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) BACE2, BACE1, PSEN2 KDM4E 3667/4885MAPT 34/4885F2 4033/4885
US-20130137730-A1 INHIBITOR OF CASEIN KINASE 1DELTA AND CASEIN KINASE 1E CSNK1A1, CSNK1G1, CSNK1A1L KDM4E 795/4885MAPT 966/4885F2 4229/4885
US-20220009914-A1 Analogs of Nitrofuran Antibiotics to Combat Resistance ATF4, ATF1, FBL KDM4E 2340/4885MAPT 4442/4885F2 4738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.