Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680870 | 0.87 | GRM5 (0.41) | GRM5HSP90AA1HSP90AB1CYP2E1CYP2A6 | |
| SCHEMBL4683613 | 0.83 | GRM5 (0.37) | GRM5HSP90AA1HSP90AB1CYP2E1CYP2A6 | |
| SCHEMBL4740959 | 0.81 | GRM5 (0.46) | GRM5 | |
| SCHEMBL4737979 | 0.77 | GRM5 (0.38) | GRM5HSP90AA1HSP90AB1 | |
| SCHEMBL4686025 | 0.75 | GRM5 (0.40) | GRM5HSP90AA1HSP90AB1CYP2E1CYP2A6 | |
| SCHEMBL6103021 | 0.75 | GRM5 (0.40) | GRM5 | |
| SCHEMBL13706965 | 0.74 | GRM5 (0.49) | GRM5HSP90AA1HSP90AB1CYP2A6CYP2C19 | |
| SCHEMBL4683032 | 0.72 | CYP19A1 (0.40) | GRM5HSP90AA1HSP90AB1CYP2E1CYP2A6 | |
| SCHEMBL4680906 | 0.72 | ALDH1A1 (0.41) | GRM5CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL4686152 | 0.71 | GRM5 (0.36) | GRM5HSP90AA1CYP2E1CYP2A6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023245-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |