SCHEMBL824602

SCHEMBL824602

Cc1nc(/N=N/c2c(C)nn(-c3ncccn3)c2N)sc1C#N

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.38
RAB9A P51151 6/20 0.38
SMN1; SMN2 Q16637 5/20 0.38
NPC1 O15118 5/20 0.38
TDP1 Q9NUW8 4/20 0.38
KMT2A Q03164 4/20 0.38
MAPK1 P28482 3/20 0.38
MEN1 O00255 3/20 0.38
HPGD P15428 2/20 0.38
ALDH1A1 P00352 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.35
HTT P42858 2/20 0.35
ALOX12 P18054 1/20 0.35
LMNA P02545 1/20 0.34
GAA P10253 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10194342 0.77 MEN1 (0.30) MAPTRAB9ASMN1; SMN2NPC1TDP1
SCHEMBL824600 0.77 MAPT (0.42) MAPTRAB9ASMN1; SMN2NPC1TDP1
SCHEMBL824565 0.76 MAPT (0.41) MAPTRAB9ASMN1; SMN2NPC1TDP1
SCHEMBL2743088 0.69 PIK3CG (0.47) MAPTRAB9ASMN1; SMN2NPC1TDP1
SCHEMBL824849 0.67 MAPT (0.60) MAPTRAB9ASMN1; SMN2NPC1TDP1
SCHEMBL13300318 0.66 PIK3CG (0.34) MAPTKMT2ALMNAGAA
SCHEMBL824567 0.66 MAPT (0.59) MAPTRAB9ASMN1; SMN2NPC1TDP1
SCHEMBL824584 0.66 MAPT (0.38) MAPTRAB9ASMN1; SMN2NPC1TDP1
SCHEMBL824842 0.65 MAPT (0.38) MAPTRAB9ASMN1; SMN2NPC1TDP1
SCHEMBL10194291 0.65 MAPT (0.39) MAPTRAB9ASMN1; SMN2NPC1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8142519-B2 Azo pigment, and pigment dispersion, coloring composition and ink composition for inkjet recording containing the same FUJIFILM CORPORATION (JP) 2012-03-27 US disclosed
US-20100258036-A1 AZO PIGMENT, AND PIGMENT DISPERSION, COLORING COMPOSITION AND INK COMPOSITION FOR INKJET RECORDING CONTAINING THE SAME FUJIFILM CORPORATION (JP) 2010-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100258036-A1 AZO PIGMENT, AND PIGMENT DISPERSION, COLORING COMPOSITION AND INK COMPOSITION FOR INKJET RECORDING CONTAINING THE SAME WNT1, CYP1A1, CYP1B1 MAPT 372/4885RAB9A 910/4885SMN1; SMN2 3717/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.