Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.73 |
| ▸ | EGLN3 | Q9H6Z9 | 6/20 | 0.62 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247310 | 0.89 | EGLN1 (0.61) | EGLN1EGLN3EGLN2HIF1AKDM4E | |
| SCHEMBL8238459 | 0.86 | EGLN1 (0.67) | EGLN1EGLN3EGLN2HIF1AKDM4E | |
| SCHEMBL5428652 | 0.85 | EGLN1 (0.66) | EGLN1EGLN3EGLN2HIF1AKDM4E | |
| SCHEMBL8244419 | 0.85 | EGLN1 (1.00) | EGLN1EGLN3EGLN2HIF1AKDM4E | |
| SCHEMBL8248294 | 0.82 | EGLN1 (0.77) | EGLN1EGLN3EGLN2HIF1AKDM4E | |
| SCHEMBL5307125 | 0.80 | EGLN1 (0.61) | EGLN1EGLN3EGLN2HIF1AKDM4E | |
| SCHEMBL1960754 | 0.80 | EGLN1 (0.71) | EGLN1EGLN3EGLN2KDM4EKCNH2 | |
| SCHEMBL8247257 | 0.79 | EGLN1 (0.60) | EGLN1EGLN3EGLN2HIF1AKDM4E | |
| SCHEMBL8245588 | 0.79 | EGLN1 (0.83) | EGLN1EGLN3EGLN2HIF1AKDM4E | |
| SCHEMBL4142379 | 0.79 | KCNH2 (0.74) | EGLN1EGLN3EGLN2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |