Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250107 | 0.95 | REN (0.66) | RENCYP3A4 | |
| SCHEMBL8248202 | 0.92 | REN (0.55) | RENCYP3A4KCNH2 | |
| SCHEMBL8247195 | 0.89 | REN (0.60) | RENCYP3A4 | |
| SCHEMBL8251233 | 0.85 | REN (0.52) | RENCYP3A4KCNH2 | |
| SCHEMBL8249798 | 0.82 | REN (0.56) | RENCYP3A4KCNH2 | |
| SCHEMBL8249943 | 0.81 | REN (0.66) | RENCYP3A4 | |
| SCHEMBL8248261 | 0.81 | REN (0.55) | RENCYP3A4KCNH2 | |
| SCHEMBL8246855 | 0.80 | REN (0.64) | RENCYP3A4KCNH2 | |
| SCHEMBL662619 | 0.79 | REN (0.92) | RENCYP3A4 | |
| SCHEMBL8241206 | 0.79 | REN (0.54) | RENCYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007009250-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-25 | — | — | WO | disclosed |