Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 10/20 | 0.81 |
| ▸ | OXTR | P30559 | 1/20 | 0.56 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355499 | 0.89 | AVPR1A (1.00) | AVPR1AOXTRNPY5RHSD11B1CYP2D6 | |
| SCHEMBL8242341 | 0.89 | AVPR1A (0.65) | AVPR1AOXTRNPY5RDGAT1 | |
| SCHEMBL4364065 | 0.82 | AVPR1A (0.87) | AVPR1AOXTRNPY5RHSD11B1CYP2D6 | |
| SCHEMBL4355431 | 0.79 | AVPR1A (0.80) | AVPR1AOXTRNPY5R | |
| SCHEMBL4357247 | 0.79 | AVPR1A (0.80) | AVPR1AOXTRNPY5R | |
| SCHEMBL5138467 | 0.79 | AVPR1A (0.80) | AVPR1AOXTRNPY5R | |
| SCHEMBL13602796 | 0.77 | AVPR1A (0.78) | AVPR1AOXTRNPY5R | |
| SCHEMBL8248461 | 0.77 | AVPR1A (0.49) | AVPR1AOXTRHSD11B1 | |
| SCHEMBL4365900 | 0.77 | AVPR1A (0.76) | AVPR1AOXTR | |
| SCHEMBL4759170 | 0.76 | AVPR1A (1.00) | AVPR1AOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007006688-A1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |