Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 7/20 | 0.59 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.59 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.59 |
| ▸ | ITGAV | P06756 | 3/20 | 0.59 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.53 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12084555 | 0.92 | ITGB1 (0.68) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL4253234 | 0.92 | ITGB1 (0.68) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL8248434 | 0.85 | ITGB1 (0.72) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL8246390 | 0.84 | ITGB1 (0.61) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL8248905 | 0.83 | ITGB1 (0.58) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL4257956 | 0.83 | ITGB1 (0.58) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL8248750 | 0.82 | L3MBTL1 (0.61) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL8238713 | 0.81 | ITGB1 (0.69) | ITGB1ITGA5ITGA4ITGA2FKBP1A | |
| SCHEMBL19426650 | 0.81 | ITGB1 (0.64) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL8244932 | 0.80 | ITGB1 (0.74) | ITGB1ITGA4ITGA2FKBP1AMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006133338-A1 | INHIBITORS OF THE α2β1/GPIa-IIa INTEGRIN | THE TRUSTEES OF THE UNIVERSITY OF PENNESYLVANIA (US) | 2006-12-14 | — | — | WO | disclosed |