Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | ADA | P00813 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1037437 | 0.85 | CYP19A1 (0.64) | CYP11B2CYP19A1 | |
| SCHEMBL15348644 | 0.75 | CYP11B2 (0.58) | CYP11B2CYP19A1ADA | |
| SCHEMBL2355664 | 0.74 | CYP19A1 (0.60) | CYP11B2CYP19A1 | |
| SCHEMBL1041429 | 0.72 | CYP11B2 (0.60) | CYP11B2CYP19A1BACE1BACE2 | |
| SCHEMBL1041634 | 0.66 | CYP11B2 (0.81) | CYP11B2CYP19A1 | |
| SCHEMBL2268465 | 0.65 | HRH3 (0.46) | POLB | |
| SCHEMBL2267755 | 0.65 | HRH3 (0.43) | POLB | |
| SCHEMBL1039271 | 0.65 | CYP11B2 (1.00) | CYP11B2CYP19A1BACE1BACE2 | |
| SCHEMBL1039095 | 0.65 | CYP11B2 (1.00) | CYP11B2CYP19A1 | |
| SCHEMBL12957226 | 0.65 | CYP11B2 (0.72) | CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270011-A1 | Condensed imidazolo derivatives for the inhibition of aromatase | Novartis AG (CH) | 2011-01-05 | — | — | EP | disclosed |
| WO-2007024945-A1 | CONDENSED IMIDAZOLO DERIVATIVES FOR THE INHIBITION OF ALDOSTERONE SYNTHASE AND AROMATASE | NOVARTIS AG (CH) | 2007-03-01 | — | — | WO | disclosed |