Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.63 |
| ▸ | ACE | P12821 | 4/20 | 0.63 |
| ▸ | FNTA | P49354 | 5/20 | 0.40 |
| ▸ | FNTB | P49356 | 5/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869721 | 1.00 | ACE2 (0.63) | ACE2ACEFNTAFNTBPGGT1B | |
| SCHEMBL1690941 | 0.92 | ACE2 (0.59) | ACE2ACEFNTAFNTBPGGT1B | |
| SCHEMBL8249946 | 0.92 | ACE2 (0.59) | ACE2ACEFNTAFNTBPGGT1B | |
| SCHEMBL1656622 | 0.89 | ACE2 (0.64) | ACE2ACEFNTAFNTBPGGT1B | |
| SCHEMBL5870153 | 0.89 | ACE2 (0.64) | ACE2ACEMMECYP11B1CYP11B2 | |
| SCHEMBL8249141 | 0.89 | ACE2 (0.64) | ACE2ACEFNTAFNTBPGGT1B | |
| SCHEMBL5869963 | 0.88 | ACE2 (0.68) | ACE2ACEFNTAFNTBPGGT1B | |
| SCHEMBL5869596 | 0.88 | ACE2 (0.63) | ACE2ACEKMT2AMMECYP11B1 | |
| SCHEMBL5870208 | 0.86 | ACE2 (0.78) | ACE2ACEFNTAFNTBMME | |
| SCHEMBL8248569 | 0.86 | ACE2 (0.78) | ACE2ACEFNTAFNTBMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | ACE2 2/4885ACE 1/4885FNTA 1718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.