Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.42 |
| ▸ | ACE | P12821 | 3/20 | 0.42 |
| ▸ | GRN | P28799 | 3/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 6/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 5/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 5/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 5/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 5/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 5/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 5/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 5/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 5/20 | 0.40 |
| ▸ | PSMA5 | P28066 | 5/20 | 0.40 |
| ▸ | PSMB4 | P28070 | 5/20 | 0.40 |
| ▸ | PSMB6 | P28072 | 5/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 5/20 | 0.40 |
| ▸ | PSMB3 | P49720 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870057 | 1.00 | ACE2 (0.42) | ACE2ACEGRNSORT1ALDH1A1 | |
| SCHEMBL5869700 | 0.83 | NOTUM (0.50) | ALDH1A1CYP2C19MAPK1 | |
| SCHEMBL8249254 | 0.83 | NOTUM (0.50) | ALDH1A1CYP2C19MAPK1 | |
| SCHEMBL5869502 | 0.79 | NOTUM (0.50) | ACE2ACEGRNSORT1ALDH1A1 | |
| SCHEMBL8248791 | 0.79 | NOTUM (0.50) | ACE2ACEGRNSORT1ALDH1A1 | |
| SCHEMBL27133930 | 0.78 | PSMB8 (0.43) | ALDH1A1PSMB8PSMB5PSMB11PSMA7 | |
| SCHEMBL26965365 | 0.78 | PSMB8 (0.43) | ALDH1A1PSMB8PSMB5PSMB11PSMA7 | |
| SCHEMBL8248796 | 0.78 | NPC1 (0.54) | ACE2GRNSORT1ALDH1A1CYP2C19 | |
| SCHEMBL5869939 | 0.78 | NPC1 (0.54) | ACE2GRNSORT1ALDH1A1CYP2C19 | |
| SCHEMBL5869392 | 0.77 | HPGD (0.50) | ACE2ACEGRNSORT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | ACE2 2/4885ACE 1/4885GRN 3026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.