Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | RARG | P13631 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.56 |
| ▸ | PPARA | Q07869 | 1/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.56 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.56 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8165462 | 0.91 | CYP2C9 (0.61) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11245255 | 0.90 | CYP1A2 (0.53) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11258506 | 0.90 | CYP1A2 (0.53) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7328108 | 0.89 | MME (0.59) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7328105 | 0.89 | MME (0.59) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7328102 | 0.89 | MME (0.59) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5916371 | 0.87 | CYP2C9 (0.57) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8249764 | 0.86 | BIRC2 (0.67) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5870418 | 0.86 | BIRC2 (0.67) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5870422 | 0.86 | BIRC2 (0.67) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | CYP2C9 1997/4885CYP2C19 1489/4885CYP1A2 827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.