Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 5/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664064 | 0.83 | REN (0.70) | RENCYP3A4 | |
| SCHEMBL8250188 | 0.81 | REN (0.63) | RENCYP3A4KCNH2 | |
| SCHEMBL8248202 | 0.81 | REN (0.55) | RENCYP3A4KCNH2 | |
| SCHEMBL8241206 | 0.81 | REN (0.54) | RENCYP3A4KCNH2 | |
| SCHEMBL8249798 | 0.81 | REN (0.56) | RENCYP3A4KCNH2 | |
| SCHEMBL8247212 | 0.80 | REN (0.49) | RENCYP3A4KCNH2 | |
| SCHEMBL8246855 | 0.80 | REN (0.64) | RENCYP3A4KCNH2 | |
| SCHEMBL10186757 | 0.77 | REN (0.71) | RENCYP3A4 | |
| SCHEMBL8246179 | 0.76 | REN (0.56) | RENCYP3A4KCNH2 | |
| SCHEMBL8247993 | 0.75 | REN (0.50) | RENCYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007009250-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-25 | — | — | WO | disclosed |