Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 10/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | POLQ | O75417 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554279 | 0.90 | IL2 (0.53) | IL2IKBKETBK1POLQABCB1 | |
| SCHEMBL8257714 | 0.85 | IL2 (0.45) | IL2POLQABCB1ABCC1 | |
| SCHEMBL5550959 | 0.85 | IL2 (0.48) | IL2IKBKETBK1LRRK2 | |
| SCHEMBL5554212 | 0.83 | IL2 (0.50) | IL2IKBKETBK1FYN | |
| SCHEMBL5550506 | 0.82 | IL2 (0.44) | IL2POLQABCB1ABCC1LRRK2 | |
| SCHEMBL5554305 | 0.82 | IL2 (0.44) | IL2POLQ | |
| SCHEMBL8258539 | 0.82 | STIM1 (0.53) | IL2 | |
| SCHEMBL5550920 | 0.81 | IL2 (0.54) | IL2 | |
| SCHEMBL5550900 | 0.76 | IL2 (0.52) | IL2ABCB1ABCC1 | |
| SCHEMBL15395956 | 0.75 | KDM4E (0.47) | IL2ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |