Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.53 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.53 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.53 |
| ▸ | IL2 | P60568 | 18/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550920 | 0.95 | IL2 (0.54) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL5554212 | 0.88 | IL2 (0.50) | STIM1ORAI1ORAI2IL2 | |
| SCHEMBL8257121 | 0.83 | STIM1 (0.61) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL5554279 | 0.83 | IL2 (0.53) | STIM1ORAI1IL2 | |
| SCHEMBL8251256 | 0.82 | IL2 (0.46) | IL2 | |
| SCHEMBL5550551 | 0.81 | IL2 (0.54) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL15214056 | 0.80 | IL2 (0.54) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL8257720 | 0.77 | IL2 (0.49) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL5555303 | 0.77 | IL2 (0.53) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL5556022 | 0.77 | STIM1 (0.53) | STIM1ORAI1ORAI2IL2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |