Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411058 | 0.91 | NEK2 (0.53) | NEK2BRAFMAP2K1ALDH1A1HTT | |
| SCHEMBL410517 | 0.89 | ALDH1A1 (0.59) | NEK2BRAFMAP2K1ALDH1A1HTT | |
| SCHEMBL415660 | 0.89 | NEK2 (0.51) | NEK2BRAFMAP2K1ALDH1A1HTT | |
| SCHEMBL857000 | 0.88 | NEK2 (0.58) | NEK2CDC7MAP2K1KMT2ARAB9A | |
| SCHEMBL413384 | 0.88 | TAAR1 (0.53) | NEK2CDC7BRAFMAP2K1ALDH1A1 | |
| SCHEMBL416184 | 0.88 | NPC1 (0.52) | NEK2BRAFMAP2K1ALDH1A1HTT | |
| SCHEMBL415961 | 0.88 | BRAF (0.53) | NEK2BRAFMAP2K1ALDH1A1HTT | |
| SCHEMBL8247093 | 0.87 | BRAF (0.52) | NEK2BRAFRIPK1MEN1KMT2A | |
| SCHEMBL414293 | 0.87 | BRAF (0.55) | NEK2BRAFMAP2K1CLK1DYRK1A | |
| SCHEMBL410657 | 0.87 | BRAF (0.62) | NEK2BRAFMAP2K1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002325-A1 | PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007002433-A1 | PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |