Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13307089 | 0.79 | GLO1 (0.53) | GLO1NPSR1FAAHALDH1A1CYP2D6 | |
| SCHEMBL7424890 | 0.79 | GLO1 (0.53) | GLO1NPSR1FAAHALDH1A1CYP2D6 | |
| SCHEMBL8337175 | 0.77 | NPSR1 (0.41) | GLO1NPSR1HCAR2FAAHALDH1A1 | |
| SCHEMBL27301100 | 0.74 | NPSR1 (0.45) | GLO1NPSR1HCAR2ALDH1A1CYP2D6 | |
| SCHEMBL14346063 | 0.72 | NPSR1 (0.43) | GLO1NPSR1HCAR2ALDH1A1CYP2D6 | |
| SCHEMBL13935951 | 0.72 | NPSR1 (0.43) | GLO1NPSR1HCAR2ALDH1A1CYP2D6 | |
| SCHEMBL13934146 | 0.71 | NPSR1 (0.42) | GLO1NPSR1HCAR2FAAHALDH1A1 | |
| SCHEMBL6531427 | 0.71 | NPSR1 (0.42) | GLO1NPSR1HCAR2FAAHALDH1A1 | |
| SCHEMBL13934158 | 0.71 | NPSR1 (0.42) | GLO1NPSR1HCAR2FAAHALDH1A1 | |
| SCHEMBL11914228 | 0.69 | NPSR1 (0.41) | GLO1NPSR1HCAR2ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006098683-A1 | 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-09-21 | — | — | WO | disclosed |