Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24752179 | 0.86 | POLB (0.44) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL24753886 | 0.86 | POLB (0.44) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL19070343 | 0.84 | HDAC6 (0.41) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL20471085 | 0.82 | HDAC6 (0.41) | POLBCASP3SENP7SENP6HDAC6 | |
| SCHEMBL12069835 | 0.82 | USP7 (0.47) | HDAC6HDAC1HDAC5HDAC4HDAC8 | |
| SCHEMBL17115059 | 0.81 | NPC1 (0.47) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL10146061 | 0.81 | POLB (0.46) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL21397907 | 0.79 | POLB (0.44) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL13618543 | 0.79 | POLB (0.44) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL13163067 | 0.78 | HDAC6 (0.43) | HDAC6HDAC1HDAC5HDAC4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006128184-A2 | PYRIMIDINE OR TRIAZINE FUSED BICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS-PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |