Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.57 |
| ▸ | MMP3 | P08254 | 2/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256282 | 0.92 | MMP13 (0.61) | MMP13ADAMTS4MMP3TRPV1P2RX7 | |
| SCHEMBL8254250 | 0.91 | MMP13 (0.52) | MMP13ADAMTS4MMP3TRPV1P2RX7 | |
| SCHEMBL10165658 | 0.90 | MMP13 (0.48) | MMP13ADAMTS4MMP3TRPV1P2RX7 | |
| SCHEMBL8252114 | 0.87 | MMP13 (0.52) | MMP13ADAMTS4MMP3MEN1KMT2A | |
| SCHEMBL8252115 | 0.87 | MMP13 (0.47) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 | |
| SCHEMBL10165576 | 0.87 | MMP13 (0.47) | MMP13ADAMTS4MMP3MAPK1RPS6KA1 | |
| SCHEMBL8256471 | 0.87 | MMP13 (0.53) | MMP13ADAMTS4MMP3TRPV1MEN1 | |
| SCHEMBL8246498 | 0.87 | MMP13 (0.50) | MMP13ADAMTS4MMP3MEN1KMT2A | |
| SCHEMBL8253265 | 0.87 | MMP13 (0.56) | MMP13ADAMTS4MMP3TRPV1P2RX7 | |
| SCHEMBL8253184 | 0.86 | MMP13 (0.52) | MMP13ADAMTS4MMP3TRPV1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006128184-A2 | PYRIMIDINE OR TRIAZINE FUSED BICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS-PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |