Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668280 | 0.79 | REN (0.48) | REN | |
| SCHEMBL4669289 | 0.74 | REN (0.44) | RENTSHR | |
| SCHEMBL4667732 | 0.73 | REN (0.48) | RENTSHRL3MBTL1KDM4E | |
| SCHEMBL8254744 | 0.71 | REN (0.76) | RENTSHRL3MBTL1 | |
| SCHEMBL13131482 | 0.70 | REN (0.72) | REN | |
| SCHEMBL4835867 | 0.70 | REN (1.00) | RENTSHR | |
| SCHEMBL4669242 | 0.70 | REN (0.46) | RENTSHRL3MBTL1KDM4E | |
| SCHEMBL8253747 | 0.69 | REN (0.72) | RENTSHRMAPK1KDM4E | |
| SCHEMBL8256616 | 0.69 | REN (0.72) | RENTSHRL3MBTL1 | |
| SCHEMBL8254479 | 0.69 | REN (0.72) | RENTSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006117183-A1 | 3 -M0N0- AND 3 , 5-DISUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2006-11-09 | — | — | WO | disclosed |