Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | IL1B | P01584 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669434 | 0.93 | REN (0.57) | RENNAMPTPDE4BMAPTUSP30 | |
| SCHEMBL4912890 | 0.93 | REN (0.57) | RENNAMPTPDE4BMAPTKDM1A | |
| SCHEMBL4912885 | 0.93 | REN (0.57) | RENNAMPTPDE4BMAPTKDM1A | |
| SCHEMBL4669437 | 0.93 | REN (0.57) | RENNAMPTPDE4BMAPTUSP30 | |
| SCHEMBL4667631 | 0.93 | REN (0.57) | RENNAMPTPDE4BMAPTUSP30 | |
| SCHEMBL4670533 | 0.93 | REN (0.57) | RENNAMPTPDE4BMAPTKDM1A | |
| SCHEMBL14089231 | 0.91 | REN (0.55) | RENKCNH2SCN5ASCN9ASTS | |
| SCHEMBL4909887 | 0.91 | REN (0.55) | RENNAMPTMAPTUSP30KDM4E | |
| SCHEMBL4916218 | 0.91 | REN (0.55) | RENKCNH2SCN5ASCN9ASTS | |
| SCHEMBL4909883 | 0.91 | REN (0.55) | RENNAMPTMAPTUSP30KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006117183-A1 | 3 -M0N0- AND 3 , 5-DISUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2006-11-09 | — | — | WO | disclosed |