Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 16/20 | 0.80 |
| ▸ | HCRTR2 | O43614 | 16/20 | 0.80 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486880 | 0.89 | HCRTR1 (1.00) | HCRTR1HCRTR2POLB | |
| SCHEMBL4477094 | 0.84 | HCRTR1 (0.81) | HCRTR1HCRTR2 | |
| SCHEMBL4486323 | 0.82 | HCRTR1 (0.82) | HCRTR1HCRTR2MAPT | |
| SCHEMBL4482621 | 0.82 | HCRTR1 (0.86) | HCRTR1HCRTR2 | |
| SCHEMBL4481940 | 0.82 | HCRTR1 (0.80) | HCRTR1HCRTR2 | |
| SCHEMBL4498250 | 0.82 | HCRTR1 (0.78) | HCRTR1HCRTR2 | |
| SCHEMBL4488195 | 0.81 | HCRTR1 (0.84) | HCRTR1HCRTR2 | |
| SCHEMBL4486211 | 0.80 | HCRTR1 (0.79) | HCRTR1HCRTR2 | |
| SCHEMBL4480261 | 0.79 | HCRTR1 (1.00) | HCRTR1HCRTR2 | |
| SCHEMBL4469637 | 0.79 | HCRTR1 (1.00) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006127550-A1 | PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-11-30 | — | — | WO | disclosed |