Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL468211 | 1.00 | ALDH1A1 (0.38) | ALDH1A1KDM4ELMNATP53TSHR | |
| SCHEMBL7369842 | 1.00 | ALDH1A1 (0.38) | ALDH1A1KDM4ELMNATP53TSHR | |
| Carbamic Acid SCHEMBL21617652 | 0.94 | ALDH1A1 (0.35) | ALDH1A1KDM4ELMNATP53TSHR | |
| SCHEMBL460381 | 0.89 | ALDH1A1 (0.37) | ALDH1A1KDM4ESMN1; SMN2MEN1MAPT | |
| SCHEMBL1960138 | 0.84 | — | — | |
| SCHEMBL14789368 | 0.81 | ATM (0.42) | ALDH1A1KDM4ELMNATP53TSHR | |
| SCHEMBL11161552 | 0.81 | ATM (0.42) | ALDH1A1KDM4ELMNATP53TSHR | |
| SCHEMBL27976966 | 0.81 | ALDH1A1 (0.34) | ALDH1A1KDM4ELMNATP53TSHR | |
| SCHEMBL28110628 | 0.78 | MAPT (0.47) | ALDH1A1KDM4ELMNATP53TSHR | |
| SCHEMBL23169131 | 0.76 | SMN1; SMN2 (0.63) | ALDH1A1KDM4ESMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576505-A1 | PROCESS FOR THE PREPARATION OF PLEUROMUTILINS | Nabriva Therapeutics AG (AT) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011146954-A1 | PROCESS FOR THE PREPARATION OF PLEUROMUTILINS | NABRIVA THERAPEUTICS AG (AT) | 2011-12-01 | — | — | WO | disclosed |