Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8253747 | 0.90 | REN (0.72) | RENTSHRKMT2AMEN1NPC1 | |
| SCHEMBL8254744 | 0.89 | REN (0.76) | RENTSHRKMT2AMEN1NPC1 | |
| SCHEMBL4911876 | 0.87 | REN (0.57) | RENMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL8256616 | 0.87 | REN (0.72) | RENTSHR | |
| SCHEMBL8254479 | 0.87 | REN (0.72) | RENTSHR | |
| SCHEMBL8248077 | 0.85 | REN (0.74) | RENTSHRKMT2AMAPTHPGD | |
| SCHEMBL4835867 | 0.83 | REN (1.00) | RENTSHRKMT2AMEN1NPC1 | |
| SCHEMBL4907824 | 0.80 | REN (1.00) | RENTSHRKMT2AMEN1MAPT | |
| SCHEMBL4909883 | 0.79 | REN (0.55) | RENMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL4909887 | 0.79 | REN (0.55) | RENMAPTKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006117183-A1 | 3 -M0N0- AND 3 , 5-DISUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2006-11-09 | — | — | WO | disclosed |