Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KLK7 | P49862 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16981649 | 0.86 | HTT (0.66) | RAB9ANPC1SMN1; SMN2HTTKMT2A | |
| SCHEMBL31185236 | 0.84 | HTT (0.68) | RAB9ANPC1SMN1; SMN2HTTKMT2A | |
| SCHEMBL29279417 | 0.84 | HTT (0.68) | RAB9ANPC1SMN1; SMN2HTTKMT2A | |
| SCHEMBL10813852 | 0.83 | HTT (0.58) | RAB9ANPC1SMN1; SMN2HTTKMT2A | |
| SCHEMBL2608943 | 0.81 | HTT (0.70) | RAB9ANPC1SMN1; SMN2HTTKMT2A | |
| SCHEMBL28716691 | 0.81 | ALDH1A1 (0.59) | RAB9ANPC1SMN1; SMN2HTTKMT2A | |
| SCHEMBL26741222 | 0.81 | ALDH1A1 (0.68) | RAB9ANPC1SMN1; SMN2HTTKMT2A | |
| SCHEMBL11645905 | 0.81 | XIAP (0.62) | RAB9ANPC1SMN1; SMN2HTTKMT2A | |
| SCHEMBL26741245 | 0.81 | ALDH1A1 (0.68) | RAB9ANPC1SMN1; SMN2HTTKMT2A | |
| SCHEMBL29410397 | 0.81 | ALDH1A1 (0.59) | RAB9ANPC1SMN1; SMN2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |