Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246479 | 0.91 | MEN1 (0.43) | MEN1KMT2APABPC1ALDH1A1KDM4E | |
| SCHEMBL8253057 | 0.90 | MEN1 (0.42) | MEN1KMT2APABPC1ALDH1A1LMNA | |
| SCHEMBL8247377 | 0.84 | KMT2A (0.44) | MEN1KMT2APABPC1ALDH1A1KDM4E | |
| SCHEMBL8256636 | 0.72 | MAPK1 (0.39) | KMT2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8247376 | 0.72 | TP53 (0.36) | MEN1KMT2APABPC1ALDH1A1KDM4E | |
| SCHEMBL8253041 | 0.71 | MEN1 (0.47) | MEN1KMT2APABPC1ALDH1A1KDM4E | |
| SCHEMBL8247063 | 0.70 | LCK (0.36) | KMT2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8255421 | 0.69 | KDM4E (0.42) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL8255673 | 0.68 | MEN1 (0.33) | MEN1KMT2APABPC1LMNA | |
| SCHEMBL17730342 | 0.66 | KMT2A (0.50) | MEN1KMT2APABPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006128184-A2 | PYRIMIDINE OR TRIAZINE FUSED BICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS-PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |