Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GALR2 | O43603 | 4/20 | 0.44 |
| ▸ | GALR1 | P47211 | 2/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8254470 | 0.90 | GALR2 (0.42) | MAPTALDH1A1HTTUSP2TDP1 | |
| SCHEMBL3244303 | 0.89 | LMNA (0.49) | MAPTLMNAGALR2GALR1CCNE1 | |
| SCHEMBL8253195 | 0.88 | MAPT (0.48) | MAPTALDH1A1HTTUSP2TDP1 | |
| SCHEMBL8256940 | 0.87 | MAPT (0.43) | MAPTALDH1A1HTTLMNAGALR2 | |
| SCHEMBL8247667 | 0.85 | GALR2 (0.43) | MAPTALDH1A1HTTUSP2TDP1 | |
| SCHEMBL8247651 | 0.85 | MAPT (0.48) | MAPTALDH1A1HTTUSP2LMNA | |
| SCHEMBL8254469 | 0.83 | SMN1; SMN2 (0.40) | MAPTALDH1A1LMNAGALR2GALR1 | |
| SCHEMBL3246394 | 0.83 | MAPT (0.57) | MAPTALDH1A1TDP1LMNAGALR2 | |
| SCHEMBL8253248 | 0.83 | GALR2 (0.55) | MAPTALDH1A1LMNAGALR2GALR1 | |
| SCHEMBL8254119 | 0.81 | KDM4E (0.48) | MAPTALDH1A1HTTLMNAGALR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082587-A1 | 2,4,6-Triaminopyrimidines for the treatment of depression and/or anxiety | H. LUNDBECK A/S (DK) | 2004-04-29 | — | — | US | disclosed |
| US-20040082587-A1 | 2,4,6-Triaminopyrimidines for the treatment of depression and/or anxiety | H. LUNDBECK A/S (DK) | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082587-A1 | 2,4,6-Triaminopyrimidines for the treatment of depression and/or anxiety | GALR3, GALR2, GALR1 | MAPT 2638/4885ALDH1A1 1395/4885HTT 1960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.