Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247831 | 0.78 | HDAC1 (0.53) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL13118156 | 0.73 | HDAC1 (0.74) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL8257577 | 0.71 | HDAC1 (0.56) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL8256489 | 0.70 | HDAC1 (0.47) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL8256872 | 0.68 | HDAC1 (0.51) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL8255178 | 0.66 | HDAC1 (0.53) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL14144824 | 0.66 | HDAC1 (0.57) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL14131675 | 0.64 | HDAC1 (0.55) | HDAC1HDAC8HDAC3HDAC2HDAC4 | |
| SCHEMBL3368459 | 0.64 | HDAC1 (1.00) | HDAC1HDAC8HDAC6 | |
| SCHEMBL3368463 | 0.64 | HDAC1 (1.00) | HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006101456-A1 | BICYCLIC HETEROCYCLES HYDROXAMATE COMPOUNDS USEFUL AS HISTONE DEACETYLASE (HDAC) INHIBITORS | S*BIO PTE LTD (SG) | 2006-09-28 | — | — | WO | disclosed |