Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 13/20 | 0.44 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.43 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8258264 | 0.89 | IL2 (0.46) | IL2STIM1ORAI1ORAI2NPC1 | |
| SCHEMBL8256457 | 0.88 | IL2 (0.44) | IL2STIM1ORAI1ORAI2KCNQ3 | |
| SCHEMBL5554338 | 0.86 | IL2 (0.48) | IL2STIM1ORAI1ORAI2KCNQ3 | |
| SCHEMBL8257607 | 0.82 | IL2 (0.42) | IL2STIM1ORAI1ORAI2KCNQ3 | |
| SCHEMBL8260146 | 0.82 | IL2 (0.39) | IL2STIM1ORAI1ORAI2NPC1 | |
| SCHEMBL8263046 | 0.82 | IL2 (0.48) | IL2STIM1ORAI1KCNQ3KCNQ2 | |
| SCHEMBL5554283 | 0.81 | IL2 (0.44) | IL2STIM1ORAI1ORAI2SMN1; SMN2 | |
| SCHEMBL5554256 | 0.81 | IL2 (0.47) | IL2STIM1ORAI1ORAI2NPC1 | |
| SCHEMBL8256962 | 0.80 | POLB (0.41) | STIM1ORAI1ORAI2RIPK2MAOB | |
| SCHEMBL15395779 | 0.80 | STIM1 (0.53) | IL2STIM1ORAI1ORAI2KCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |