Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8252236 | 0.91 | ALDH1A1 (0.39) | POLBUSP2HTTALDH1A1MAOA | |
| SCHEMBL8259763 | 0.88 | POLB (0.41) | POLBUSP2HTTALDH1A1MAOA | |
| SCHEMBL8257487 | 0.83 | POLB (0.40) | POLBUSP2HTTALDH1A1MAOA | |
| SCHEMBL8263036 | 0.83 | POLB (0.42) | POLBUSP2HTTALDH1A1MAOA | |
| SCHEMBL15395955 | 0.82 | POLB (0.50) | POLBUSP2HTTALDH1A1MAOA | |
| SCHEMBL8260146 | 0.80 | IL2 (0.39) | HTTSTIM1ORAI1ORAI2MAPT | |
| SCHEMBL8256955 | 0.80 | IL2 (0.44) | POLBMAOBSTIM1ORAI1ORAI2 | |
| SCHEMBL8260160 | 0.79 | LMNA (0.38) | POLBUSP2HTTALDH1A1LMNA | |
| SCHEMBL8260246 | 0.79 | LMNA (0.39) | POLBUSP2HTTALDH1A1LMNA | |
| SCHEMBL8258264 | 0.78 | IL2 (0.46) | STIM1ORAI1ORAI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |