⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14028663 | 0.72 | — | — | |
| SCHEMBL8823853 | 0.64 | — | — | |
| SCHEMBL6357876 | 0.60 | — | — | |
| SCHEMBL6357877 | 0.60 | — | — | |
| SCHEMBL12386581 | 0.60 | — | — | |
| SCHEMBL19719766 | 0.60 | — | — | |
| SCHEMBL9912004 | 0.60 | — | — | |
| SCHEMBL14397335 | 0.57 | — | — | |
| SCHEMBL83596 | 0.53 | — | — | |
| SCHEMBL18342514 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249028-A1 | Thyrotropin-Releasing Hormone Analogs and Method of Use | ROGER WILLIAMS HOSPITAL (US) | 2008-10-09 | — | — | US | disclosed |
| WO-2006096829-A2 | THYROTROPIN-RELEASING HORMONE ANALOGS AND METHOD OF USE | ROGER WILLIAMS HOSPITAL (US) | 2006-09-14 | — | — | WO | disclosed |
| US-4800201-A | 1,4-thiazine derivative, and cardiotonic agent comprising it as effective component | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-01-24 | — | — | US | disclosed |
| EP-0233287-A1 | 1,4-THIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND CARDIOTONICS CONTAINING THE SAME | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 1987-08-26 | — | — | EP | disclosed |