SCHEMBL8257403

SCHEMBL8257403

CCCCCN/C(=N\C)NN

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.44
EPHX1 P07099 8/20 0.43
CASP2 P42575 1/20 0.39
DPP7 Q9UHL4 2/20 0.39
GRIN2D O15399 1/20 0.38
GRIN3B O60391 1/20 0.38
GRIN1 Q05586 1/20 0.38
GRIN2A Q12879 1/20 0.38
GRIN2B Q13224 1/20 0.38
GRIN2C Q14957 1/20 0.38
GRIN3A Q8TCU5 1/20 0.38
SIGMAR1 Q99720 1/20 0.38
ZDHHC20 Q5W0Z9 1/20 0.37
ZDHHC2 Q9UIJ5 1/20 0.37
NAAA Q02083 1/20 0.37
ALDH1A1 P00352 1/20 0.37
TSHR P16473 1/20 0.37
RRM1 P23921 1/20 0.36
SPHK1 Q9NYA1 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21064892 0.79 KDM1A (0.64) KDM1AEPHX1CASP2ZDHHC20ZDHHC2
SCHEMBL14868285 0.77 SPHK1 (0.40) KDM1AEPHX1CASP2DPP7GRIN2D
SCHEMBL14932687 0.74 GRIN2D (0.55) EPHX1CASP2DPP7GRIN2DGRIN3B
SCHEMBL12344215 0.74 KDM1A (0.69) KDM1AEPHX1GRIN2DGRIN3BGRIN1
SCHEMBL14289074 0.74 KDM1A (0.42) KDM1A
SCHEMBL11484378 0.73 HRH4 (0.51) KDM1AEPHX1CASP2ZDHHC20ZDHHC2
SCHEMBL14868278 0.71 GRIN2D (0.43) KDM1AEPHX1GRIN2DGRIN3BGRIN1
SCHEMBL1395514 0.70 EPHX1 (0.71) EPHX1CASP2DPP7ALDH1A1
SCHEMBL4051612 0.70 EPHX1 (0.46) EPHX1CASP2DPP7ALDH1A1TSHR
SCHEMBL4400254 0.70 EPHX1 (0.46) EPHX1CASP2DPP7ZDHHC20ZDHHC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006116953-A1 A METHOD FOR THE PREPARATION OF TEGASEROD AND SLECTED SALTS THEREOF ZENTIVA, A.S. (CZ) 2006-11-09 WO disclosed