Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923834 | 0.91 | REN (0.37) | RENMEN1MAPTCRHBPHTT | |
| SCHEMBL13498080 | 0.91 | REN (0.37) | RENMEN1MAPTCRHBPHTT | |
| SCHEMBL2923764 | 0.90 | REN (0.37) | RENMEN1MAPTCRHBPHTT | |
| SCHEMBL3464412 | 0.90 | REN (0.37) | RENMEN1MAPTCRHBPHTT | |
| SCHEMBL8259080 | 0.89 | REN (0.36) | RENMEN1MAPTCRHBPHTT | |
| SCHEMBL3464431 | 0.89 | REN (0.36) | RENMEN1MAPTCRHBPHTT | |
| SCHEMBL2925073 | 0.89 | REN (0.36) | RENMAPTSMN1; SMN2THRBRORC | |
| SCHEMBL2925028 | 0.89 | REN (0.36) | RENMAPTSMN1; SMN2THRBRORC | |
| SCHEMBL2919377 | 0.88 | REN (0.37) | RENMAPTSMN1; SMN2KCNH2THRB | |
| SCHEMBL13435408 | 0.87 | REN (0.35) | RENMEN1MAPTCRHBPHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006103277-A2 | 2 , 4 , 5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-10-05 | — | — | WO | disclosed |