Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4183601 | 0.82 | NR1H2 (0.49) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL31067476 | 0.81 | NR1H2 (0.60) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL4165540 | 0.81 | NR1H2 (0.60) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL8257610 | 0.81 | NR1H2 (0.55) | ESR2NR1H2ADORA1MAPK1MAPT | |
| SCHEMBL4931191 | 0.80 | NR1H2 (0.45) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL4929482 | 0.79 | NR1H2 (0.55) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL8243756 | 0.79 | NR1H2 (0.41) | ESR2NR1H2UCHL1MAPK1NPC1 | |
| SCHEMBL29405503 | 0.78 | ESR2 (0.55) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL19642882 | 0.78 | ESR2 (0.55) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL20367262 | 0.78 | ESR2 (0.54) | ESR2NR1H2UCHL1ADORA1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006108709-A1 | 3-SULFONYLAMINO-PYRROLIDINE-2-ONE DERIVATIVES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-10-19 | — | — | WO | disclosed |