Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259202 | 0.94 | LMNA (0.43) | CHRM1POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL12199159 | 0.87 | LMNA (0.45) | CHRM1POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL12131804 | 0.85 | CHRM1 (0.53) | CHRM1ALDH1A1CHRM2 | |
| SCHEMBL13176007 | 0.84 | SMN1; SMN2 (0.38) | CHRM1POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL12199020 | 0.84 | CHRM1 (0.43) | CHRM1CHRM2CHRM3 | |
| SCHEMBL21712561 | 0.81 | SMN1; SMN2 (0.45) | CHRM1POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL29461904 | 0.81 | MAPK1 (0.42) | CHRM1POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL30532513 | 0.80 | LMNA (0.42) | CHRM1POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL30068327 | 0.80 | LMNA (0.42) | CHRM1POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL12086277 | 0.80 | LMNA (0.42) | CHRM1POLBLMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2228364-A1 | Acylsulfonamides as inhibitors of steroid sulfatase | Novartis AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2006097293-A2 | COMBINATION OF A STEROID SULFATASE INHIBITOR AND AN ASCOMYCIN | NOVARTIS AG (CH) | 2006-09-21 | — | — | WO | disclosed |