Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2925854 | 1.00 | REN (0.34) | RENRORCALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL2922315 | 0.95 | REN (0.37) | RENRORC | |
| SCHEMBL2924373 | 0.93 | REN (0.32) | REN | |
| SCHEMBL3550462 | 0.93 | REN (0.34) | RENRORCALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL8258484 | 0.93 | REN (0.34) | RENRORCALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL2947415 | 0.93 | REN (0.34) | RENRORCALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL2923670 | 0.91 | REN (0.34) | RENRORCALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL8473762 | 0.91 | REN (0.34) | RENRORCALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL2922006 | 0.91 | REN (0.34) | RENRORCALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL8257866 | 0.91 | REN (0.35) | RENRORCALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1958634-A2 | Substituted piperidines as inhibitors of beta-secretase, cathepsin D, plasmepsin II and/or HIV protease | Speedel Experimenta AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| WO-2006103277-A2 | 2 , 4 , 5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-10-05 | — | — | WO | disclosed |