SCHEMBL8258982

SCHEMBL8258982

COc1cccc(CCC(=O)N2C3CCC(CC3)C2C(=O)N[C@@H](Cc2ccc(NC(=O)c3c(Cl)cncc3Cl)cc2)C(=O)O)c1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 20/20 0.53
ITGB1 P05556 18/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8293507 0.82 ITGA4 (0.51) ITGA4ITGB1
SCHEMBL5804893 0.80 ITGA4 (0.64) ITGA4ITGB1
SCHEMBL5806399 0.78 ITGB1 (0.52) ITGA4ITGB1
SCHEMBL8258817 0.78 ITGB1 (0.52) ITGA4ITGB1
SCHEMBL5807957 0.75 ITGA4 (0.58) ITGA4ITGB1
SCHEMBL8293511 0.72 ITGA4 (0.40) ITGA4ITGB1
SCHEMBL6530895 0.71 ITGB1 (0.78) ITGA4ITGB1
SCHEMBL6469445 0.70 ITGA4 (0.60) ITGA4ITGB1
SCHEMBL6469442 0.70 ITGA4 (0.60) ITGA4ITGB1
SCHEMBL5200859 0.69 ITGA4 (0.68) ITGA4ITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006096807-A1 AZA-BRIDGED-BICYCLIC AMINO ACID DERIVATIVES AS ALPHA 4 INTEGRIN ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2006-09-14 WO disclosed