SCHEMBL825911

SCHEMBL825911

CCN1C(=O)NC(=O)C(C)(N2C(=O)c3c(F)c(F)c(F)c(F)c3C2=O)C1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL825945 0.88 SMN1; SMN2 (0.33)
SCHEMBL825888 0.81 SMN1; SMN2 (0.32)
SCHEMBL10046424 0.79 TNF (0.34)
SCHEMBL825859 0.79 MEN1 (0.33)
SCHEMBL14402218 0.78 TNF (0.30)
SCHEMBL14402350 0.74 TNF (0.34)
SCHEMBL7567498 0.71 F2 (0.43)
SCHEMBL18155542 0.71 ALDH1A1 (0.36)
SCHEMBL825848 0.70 TNF (0.37)
SCHEMBL825905 0.70 SMN1; SMN2 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2004614-B1 TETRAHALOGENATED COMPOUNDS USEFUL AS INHIBITORS OF ANGIOGENESIS US GOV HEALTH & HUMAN SERV (US) 2016-10-19 EP disclosed
US-8143252-B2 Tetrahalogenated compounds useful as inhibitors of angiogenesis THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2012-03-27 US disclosed
US-8143252-B2 Tetrahalogenated compounds useful as inhibitors of angiogenesis THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2012-03-27 US disclosed
US-8143252-B2 Tetrahalogenated compounds useful as inhibitors of angiogenesis THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2012-03-27 US disclosed
US-20090186913-A1 Tetrahalogenated compounds useful as inhibitors of angiogenesis THE GOVERNMENT OF THE UNITED STATES OF AMERICA DEPARTMENT OF HEALTH AND HUMAN SERVICES 2009-07-23 US disclosed
US-20090186913-A1 Tetrahalogenated compounds useful as inhibitors of angiogenesis THE GOVERNMENT OF THE UNITED STATES OF AMERICA DEPARTMENT OF HEALTH AND HUMAN SERVICES 2009-07-23 US disclosed
US-20090186913-A1 Tetrahalogenated compounds useful as inhibitors of angiogenesis THE GOVERNMENT OF THE UNITED STATES OF AMERICA DEPARTMENT OF HEALTH AND HUMAN SERVICES 2009-07-23 US disclosed
EP-2004614-A1 TETRAHALOGENATED COMPOUNDS USEFUL AS INHIBITORS OF ANGIOGENESIS The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services (US) 2008-12-24 EP disclosed
WO-2007120669-A1 TETRAHALOGENATED COMPOUNDS USEFUL AS INHIBITORS OF ANGIOGENESIS THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2007-10-25 WO disclosed
WO-2007120669-A1 TETRAHALOGENATED COMPOUNDS USEFUL AS INHIBITORS OF ANGIOGENESIS THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2007-10-25 WO disclosed